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Versuche zur Biotinsynthese. Herstellung von (3a S , 6a R )‐1, 3‐Dibenzyl‐tetrahydro‐4 H ‐thieno[3, 4‐ d ]imidazol‐2,4(1 H )‐dion
Author(s) -
Gerecke M.,
Zimmermann J.P.,
Aschwanden W.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530514
Subject(s) - chemistry , thiolactone , enantiomer , stereochemistry , medicinal chemistry
A modification of the biotin synthesis of Goldberg & Sternbach is described, enantiomers being separated in the first steps and wrong isomers recyclised. The conversion of the lactone 15 to the thiolactone 16 is done by a new method using potassium thioacetate in high boiling solvents.