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Synthèse par réaction de Friedel‐Crafts d'analogues partiellement saturés de l'amitriptyline. 1 re Communication sur les antidépresseurs et les neuroleptiques tricycliques
Author(s) -
Dostert P.,
Kyburz E.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530503
Subject(s) - chemistry , tricyclic , amitriptyline , amine gas treating , antidepressant , medicinal chemistry , stereochemistry , pharmacology , organic chemistry , psychiatry , anxiety , medicine , psychology
It is postulated that one aromatic ring and the amine group in the side chain could be sufficient for the specific fixation of the molecule of a tricyclic antidepressant and for warranting its activity. Some partially saturated derivatives of amitriptyline were prepared, in order to check if pharmacologic activity is retained.