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Isolierung und Struktur der Antibiotica Phomin und 5‐Dehydrophomin
Author(s) -
Rothweiler W.,
Tamm Ch.
Publication year - 1970
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19700530404
Subject(s) - chemistry , phoma , antibiotics , stereochemistry , isoindole , lactone , botany , biochemistry , biology
From cultures of a Phoma species (strain S 298) ( Fungi imperfecti ) two new antibiotics, phomine ( 1 ) and 5‐dehydrophomine ( 4 ) have been isolated. Phomine and 5‐dehydrophomine represent a novel type of macrolide antibiotics, the large lactone ring being fused to a highly substituted octahydro‐isoindole system. Both show cytostatic activity.