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Le blocage de la lysine par la réaction de M AILLARD . I. Synthèse de N‐(désoxy‐1‐ D ‐fructosyl‐1)‐ et N‐(désoxy‐1‐ D ‐lactulosyl‐1)‐ L ‐lysines
Author(s) -
Finot P. A.,
Mauron J.
Publication year - 1969
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19690520609
Subject(s) - chemistry , lysine , pyridine , formic acid , acetic acid , stereochemistry , chromatography , amino acid , medicinal chemistry , biochemistry
The authors describe a specific method for the preparation of Nϵ‐(1‐deoxy‐D‐fructosyl)‐L‐lysine, Nα‐(1‐deoxy‐D‐fructosyl)‐L‐lysine, their formyl derivatives, and Nα‐formyl‐ϵ‐(1‐deoxy‐D‐lactulosyl)‐L‐lysine, as well as Nα, Nϵ‐di‐(1‐deoxy‐D‐fructosyl)‐L‐lysine. After purification by cation‐exchange chromatography using volatile pyridine‐acetic acid or pyridine‐formic acid buffers, these compounds are obtained in the pure state. By thin‐layer chromatography and paper electrophoresis these lysine derivatives can be rapidly separated and identified.