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Synthese von 3‐(2,4,5‐Trihydroxyphenyl)‐ DL ‐alanin
Author(s) -
Langemann A.,
Scheer M.
Publication year - 1969
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19690520425
Subject(s) - chemistry , hydantoin , hydrolysis , hydrobromic acid , alanine , condensation , catalysis , stereochemistry , organic chemistry , amino acid , biochemistry , physics , thermodynamics
Condensation of 2.4.5‐trimethoxybenzaldehyde with hydantoin followed by catalytic hydrogenation gave 5‐(2.4.5‐trimethoxybenzyl)‐hydantoin, which was converted to 3‐amino‐3.4‐dihydro‐6.7‐dihydroxycoumarin by treatment with hydrobromic acid. Hydrolysis of the lactone led to 3‐(2.4.5‐trihydroxyphenyl)‐ DL ‐alanine.