Synthese von  rac‐threo  und  rac‐erythro ‐α‐(2, 2‐Dichloracetamido)‐β‐hydroxy‐ p ‐nitrohydrozimtaldehyd | Zendy

Zanetti G. | Zendy; Vogler K. | Zendy

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Synthese von rac‐threo und rac‐erythro ‐α‐(2, 2‐Dichloracetamido)‐β‐hydroxy‐ p ‐nitrohydrozimtaldehyd

Author(s) -

Zanetti G.,

Vogler K.

Publication year - 1969

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19690520407

Subject(s) - chemistry , diastereomer , chloramphenicol , stereochemistry , antibiotics , biochemistry

rac ‐ threo ‐α‐(2, 2‐Dichloroacetamido)‐β‐hydroxy‐ p ‐nitrohydrocinnamaldehyde (3) and rac ‐ erythro ‐α‐(2, 2‐dichloroacetamido)‐β‐hydroxy‐ p ‐nitrohydrocinnamaldehyde (4) were synthesized starting from α‐acetamido‐ p ‐nitroacetophenone (7) , and their structures were proved b n− reduction to rac ‐chloramphenicol (19) and rac ‐ erythro ‐2‐(2, 2‐dichloroacetamido)‐1‐( p ‐nitrophenyl) v 1, 3‐propanediol (14) respectively. 3 exhibited only low antibacterial activity compared to rac ‐chloramphenicol (19) .

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