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Menschliches Calcitonin. IV Die Synthese von Calcitonin M. Vorläufige Mitteilung
Author(s) -
Sieber P.,
Brugger M.,
Kamber B.,
Riniker B.,
Rittel W.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19680510825
Subject(s) - chemistry , cystine , calcitonin , stereochemistry , biochemistry , endocrinology , enzyme , medicine , cysteine
A preliminary account is giver of the synthesis of calcitonin M (I), isolated from human C‐cell tumour tissue [2] [3]. Identity of the synthetic and the natural hormone was established by thin‐layer chromatography, thin‐layer electrophoresis and conversion to oxidation products, as well as by reference to the pattern of tryptic degradation and by comparing the biological activity of the two hormones. The findings also afforded additional confirmation of the results of structural elucidation [1]. In the synthesis of I, use was made of methods described previously [4] for the preparation of porcine α‐thyrocalcitonin, and also of a new method [5] which easily permits the formation of cyclic cystine peptides.