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Synthese von substituierten 1, 2‐Malonyl‐1,2‐dihydrocinnolinen (1,3‐Dioxo‐2, 3‐dihydro‐1 H ‐pyrazolo [1, 2‐a] cinnolinen) mit antiinflammatorischen Eigenschaften
Author(s) -
Schatz F.,
WagnerJauregg Th.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19680510813
Subject(s) - chemistry , hydrolysis , stereochemistry , medicinal chemistry , organic chemistry
A new class of antiphlogistic substances is described. They are 4‐phenyl‐1, 2‐dihydrocinnolins diacylated in 1, 2‐position by alkylmalonic acids. The compound which pharmacologically has been investigated most thoroughly is cinnopentazone (II). Its synthesis and behaviour towards hydrolytic and oxidative agents are described. Some relations between the chemical structure of these series of substances and their antiinflammatory activity as well as their classification as antiphlogistics according to some model reactions are discussed.