Beiträge zur Chemie der Pyrrolo[3,2‐c]azepine und der Pyrrolo [3,2‐b]azepine | Zendy

Troxler F. | Zendy; Stoll André P. | Zendy; Niklaus P. | Zendy

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Beiträge zur Chemie der Pyrrolo[3,2‐c]azepine und der Pyrrolo [3,2‐b]azepine

Author(s) -

Troxler F.,

Stoll André P.,

Niklaus P.

Publication year - 1968

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19680510808

Subject(s) - chemistry , azepine , oxalyl chloride , alkylation , hydrazine (antidepressant) , lactam , medicinal chemistry , chloride , nuclear magnetic resonance spectroscopy , hydrate , stereochemistry , organic chemistry , catalysis , chromatography

Some chemical transformations in the series of the pyrrolo [3,2‐b]azepines and the pyrrolo[3,2‐c]azepines are reported: alkylation at the pyrrolo nitrogen and/or the azepino nitrogen, reduction of the lactam group by means of LiAlH 4 , preparation of lactim ethers and amidines, substitution in position 2 by M ANNICH reaction, bromination and condensation with oxalyl chloride or chloral hydrate, and the cyclocondensation with dimethylmalonyl chloride. The structures of the 2‐substitution products have been evaluated by NMR.‐spectroscopy.

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