Premium
Beiträge zur Chemie der Pyrrolo[3,2‐c]azepine und der Pyrrolo [3,2‐b]azepine
Author(s) -
Troxler F.,
Stoll André P.,
Niklaus P.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19680510808
Subject(s) - chemistry , azepine , oxalyl chloride , alkylation , hydrazine (antidepressant) , lactam , medicinal chemistry , chloride , nuclear magnetic resonance spectroscopy , hydrate , stereochemistry , organic chemistry , catalysis , chromatography
Some chemical transformations in the series of the pyrrolo [3,2‐b]azepines and the pyrrolo[3,2‐c]azepines are reported: alkylation at the pyrrolo nitrogen and/or the azepino nitrogen, reduction of the lactam group by means of LiAlH 4 , preparation of lactim ethers and amidines, substitution in position 2 by M ANNICH reaction, bromination and condensation with oxalyl chloride or chloral hydrate, and the cyclocondensation with dimethylmalonyl chloride. The structures of the 2‐substitution products have been evaluated by NMR.‐spectroscopy.