Der oxydative Abbau von Roridin A, ein weiterer Beweis für die Art der Verknüpfung der Roridinsäure mit Verrucarol. Verrucarine und Roridine, 17. Mitteilung [1] | Zendy

Achini R. | Zendy; Tamm Ch. | Zendy

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Der oxydative Abbau von Roridin A, ein weiterer Beweis für die Art der Verknüpfung der Roridinsäure mit Verrucarol. Verrucarine und Roridine, 17. Mitteilung [1]

Author(s) -

Achini R.,

Tamm Ch.

Publication year - 1968

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19680510728

Subject(s) - chemistry , stereochemistry , epoxide , medicinal chemistry , organic chemistry , catalysis

Epoxidation of di‐O‐acetyl‐roridin A ( 2 ) gave the two mono‐epoxides 3 (not pure) and 4 (main product) and the di‐epoxide 5 . Subsequent treatment of 4 with ozone and NaBH 4 led to the esters 6 and 8 . They yielded the acetylderivatives 7 and 9 respectively. Since the degradation products prove the sites of the ester linkages also in roridin A ( 1 ), the structure of this antibiotic is proved beyond any doubt.

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