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Präparative Verwendung von Mannich‐Basen von Hydroxy‐indolen als Alkylierungsmittel. 4. Mitteilung über synthetische Indol‐Verbindungen [1]
Author(s) -
Troxler Franz
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19680510604
Subject(s) - chemistry , tryptamines , indole test , malonate , stereochemistry , benzene , medicinal chemistry , organic chemistry , tryptamine , biochemistry
The M ANNICH bases 4‐dimethylaminomethyl‐5‐hydroxy‐indole and 7‐dimethylaminomethyl‐6‐hydroxy‐indole are suitable agents for alkylating C‐acidic compounds such as nitroalkanes and ethyl formamido‐malonate. The products obtained have been transformed into (substit.) aminoethyl derivatives or amino‐acids containing the basic side‐chain in the benzene nucleus and which are, therefore, isomeric to tryptamines and tryptophans.