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Zum chemischen Verhalten des Antiphlogisticums «Azapropazon» (Mi 85) = 3‐Dimethylamino‐7‐methyl‐1,2‐(n‐propylmalonyl)‐1,2‐dihydro‐1,2,4‐benzotriazin
Author(s) -
Mixich G.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19680510317
Subject(s) - chemistry , oxidizing agent , ring (chemistry) , medicinal chemistry , molecule , stereochemistry , organic chemistry
The chemical properties of the new antiphlogistic substance Mi 85 (generic name ‘Azapropazone’), which contains a 1,2,4‐benzotriazine ring condensed to a 3,5‐dioxo‐pyrazolidine ring, were investigated. It is shown that this molecule is relatively easily attacked by various chemical reactants (scheme) mainly in the 3,5‐dioxo‐pyrazolidine ring and on the dimethylamino group. There are essential differences between Azapropazone and Phenylbutazone concerning their stability towards hydrolyzing and oxidizing agents.