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Recherches sur la formation et la transformation des esters LXXVIII. Sur la réaction de l'isothiocyanate d' o ‐méthoxycarbonyl‐phényle avec des diamines et l'hydrazine, et sur la cyclisation de quelques N‐phényl‐N′‐hydroxyalcoyl‐thio‐urées
Author(s) -
Cherbuliez Emile,
Willhalm B.,
Jaccard S.,
Rabinowitz J.
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500843
Subject(s) - chemistry , medicinal chemistry , isothiocyanate , organic chemistry
1‐Amino‐2‐dimethylamino‐ethane and 1‐amino‐3‐dimethylamino‐propane react with o ‐methoxycarbonylphenyl isothiocyanate (I) to yield the corresponding 3‐(ω‐dimethylaminoalkyl)‐2‐thiono‐1,2,3,4‐tetrahydroquinazolin‐4‐ones (V). The tertiary amino group of V is quaternized to the corresponding ammonio derivative VI when treated with methyl iodide in methanol.