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Rac. cis ‐ und trans ‐ 1, 2‐Dimethyl‐4‐hydroxy‐6, 7‐dimethoxy‐1, 2, 3, 4‐tetrahydro‐isochinolin, Synthese und Stereochemie
Author(s) -
Grethe G.,
Uskokovice M.,
Williams T.,
Brossi A.
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500826
Subject(s) - chemistry , isoquinoline , stereochemistry , nmr spectra database , medicinal chemistry , spectral line , physics , astronomy
Abstract The synthesis of rac. cis ‐ and trans ‐1,2‐dimethyl‐4‐hydroxy‐6,7‐dimethoxy‐1,2,3,4‐tetrahydro‐isoquinoline (respectively 8 and 9 ) is described. The relative configuration of these amino alcohols was determined by a detailed analysis of nmr.‐ and ir.‐spectra. The comparison of the nmr.‐spectra of 8 and 9 with that of gigantine reveals the non identity of these compounds.