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Ternäre Komplexe in Lösung IV. Einfluss von 2,2′‐Bipyridyl auf Stabilität und Acidität des Cu 2+ ‐Adenosin‐5′‐monophosphat‐N(1)‐oxid‐1:1‐Komplexes
Author(s) -
Sigel Helmut,
Prijs Bernhard
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500821
Subject(s) - chemistry , adenosine monophosphate , medicinal chemistry , adenosine , stereochemistry , phosphate , ternary operation , ligand (biochemistry) , receptor , organic chemistry , biochemistry , computer science , programming language
The ternary Cu 2+ −2,2′‐bipyridyl‐adenosine‐5′‐monophosphate‐N(1)‐oxide complex was investigated and compared with the binary Cu 2+ ‐adenosine‐5′‐monophosphate‐N(1)‐oxide complex (I) (cf. [2]). In both complexes Cu 2+ is bound to the o ‐amino‐N‐oxide group of adenosine‐5′‐monophosphate‐N(1)‐oxide (HL). The stabilities of the complexes monoprotonated at the phosphate group are of the same order: log K Cu CuHL= 11,20, and log K CuBipy CuBipyHL= 11,19. The acidity constants for the deprolonation of the phosphate group in these complexes are slightly different (pK H CuHL= 5,55, and p K H CuBipyHL= 5,88), but as expected both values are lower than the corresponding value p K H H 2 L= 6,12 of the ligand.