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Organische Phosphorverbindungen XXIX. Eine neue Methode zur Darstellung von dialkylaminomethylsubstituierten Phosphonig‐ und Phosphinsäuren der allgemeinen Formel R 2 NCH 2 PH(O)OH und (R 2 NCH 2 ) 2 P(O)OH [1]
Author(s) -
Maier Ludwig
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500705
Subject(s) - chemistry , formaldehyde , hydroxymethyl , amine gas treating , medicinal chemistry , stereochemistry , organic chemistry
A new method for the preparation of dialkylaminomethyl‐phosphonous and‐phosphinic acids, R 2 NCH 2 P(O)H(OH) and (R 2 NCH 2 ) 2 P(O)OH, is described. This involves reaction of hypophosphorous acid with hydroxymethyl‐dialkyl‐amines or a mixture of formaldehyde and a secondary amine.andThe crystalline acids form monohydrates which are stable up to the melting points of the acids. The IR. and 31 P‐NMR. spectra are reported.