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Isochinoline. 2. Mitteilung [1]. Die Alkoholyse von 1‐Chlor‐3‐chlormethyl‐4‐methyl‐isochinolin und von 1‐Chlor‐4‐chlormethyl‐3‐methyl‐isochinolin
Author(s) -
Marquardt F.H.
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500605
Subject(s) - chemistry , isoquinoline , yield (engineering) , medicinal chemistry , physics , thermodynamics
Abstract Methanolysis and ethanolysis of 1‐chloro‐3‐chloromethyl‐4‐methyl‐isoquinoline yield respectively 3‐methoxymethyl‐4‐methyl‐isocarbostyril and 3‐ethoxymethyl‐4‐methyl‐isocarbostyril as main products, together with some 3‐chloromethyl‐4‐methyl‐isocarbostyril. By analogous reactions, 1‐chloro‐4‐chloromethyl‐3‐methyl‐isoquinoline yields 4‐methoxymethyl‐3‐methyl‐isocarbostyril and 4‐ethoxymethyl‐3‐methyl‐isocarbostyril.