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Oxydative Umwandlung von 17‐Alkoxy‐aspidospermidin‐Derivaten in 17, 17‐Dialkoxy‐17, 18‐dihydro‐1, 18‐dehydro‐aspidospermidine
Author(s) -
Bycroft B. W.,
Goldman L.,
Schmid H.
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500502
Subject(s) - chemistry , methanol , sodium hydroxide , alkoxy group , iodine , medicinal chemistry , organic chemistry , ethanol , alkyl
Treatment of 17‐alkoxy‐aspidospermidine derivatives with iodine and sodium hydroxide in methanolic or ethanolic solution yields the corresponding 17, 17‐dialkoxy‐17, 18‐dihydro‐1, 18‐dehydro‐aspidospermidine. Hence compounds 1 and 2 in methanol give the oxidation products 8 and 3 , respectively. In ethanol, 4 is converted to 5 , 2 to a mixture of 6 and 7 ; 4 in methanol yields a mixture of 6 and 7 in a different ratio.