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Über die gas‐chromatographische Bestimmung von Amphetamin als (1‐phenyl‐isopropyl)‐isothiocyanat
Author(s) -
Brandenberger H.,
Hellbach Esther
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500319
Subject(s) - chemistry , isopropyl , carbon disulfide , mass spectrometry , chromatography , gas chromatography , disulfide bond , isothiocyanate , phenyl isothiocyanate , medicinal chemistry , organic chemistry , biochemistry
Amphetamine (I) reacts spontaneously at room temperature with carbon disulfide to form (1‐phenyl‐isopropyl)‐isothiocyanate, which was identified by UV.‐, IR.‐ and mass spectrometry. This reaction is used for the analytical determination of I by gas chromatography. The characteristic peak shift which occurs after addition of carbon disulfide differentiates I from N‐methylamphetamine (II). The method is applied to urine analysis of I and II (which partially metabolizes to I) and might be useful in doping control.