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über Struktur und Aktivität der den H 2 O 2 ‐Zerfall katalysierenden Cu 2+ ‐Komplexe VII
Author(s) -
Sigel H.
Publication year - 1967
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19670500223
Subject(s) - chemistry , chelation , metal , copper , ligand (biochemistry) , stereochemistry , medicinal chemistry , inorganic chemistry , receptor , organic chemistry , biochemistry
It has been stated in a preceding paper [3] that only parts of a ligand coordinated to a metal ion can be oxidized by H 2 O 2 (= peroxidative activity). Considering the reversal of this statement to be true, it is shown by means of the peroxidative activity of the Cu 2+ ‐complexes of ATP, ITP, CTP, UTP, and TTP that in these complexes the heteroaromatic groups contribute to the coordination of Cu 2+ ion. By analogy with the Cu 2+ ‐ATP‐complex, where a macrocyclic phosphate‐metal‐adenine chelate is formed [4], and based on his experimental results, the author considers the existence of such a macrocyclic chelate in the copper complexes of ITP, GTP, CTP, UTP, and TTP as established. The coordination sites of the heteroaromatic groups in these complexes are discussed.