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Un substrat pour le dosage chimique de la rénine
Author(s) -
Roth M.,
Reinharz Anja
Publication year - 1966
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19660490625
Subject(s) - chemistry , incubation , aminopeptidase , substrate (aquarium) , stereochemistry , enzyme , renin–angiotensin system , medicinal chemistry , biochemistry , amino acid , leucine , medicine , oceanography , geology , blood pressure
A fluorogenic renin substrate, N‐CBO‐ L ‐prolyl‐ L ‐phenylalanyl‐ L ‐histidyl‐ L ‐leucyl‐ L ‐leucyl‐ L ‐valyl‐ L ‐tyrosyl‐ L ‐seryl‐β‐naphthylamide, has been synthesized. Upon incubation at pH 5,6 with renin and an excess of the auxiliary enzyme aminopeptidase M, it gives rise to β‐naphthylamine at a rate related to the quantity of renin.