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De la chimie des ptérines. 15 e communication. Hydroxylation non‐enzymatique de la phénylalanine en tyrosine à l'aide de ptérines tétrahydrogénées
Author(s) -
Bobst A.,
Viscontini M.
Publication year - 1966
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19660490209
Subject(s) - chemistry , hydroxylation , aqueous solution , tyrosine , phenylalanine , enzyme , stereochemistry , medicinal chemistry , biochemistry , organic chemistry , amino acid
The non‐enzymatic hydroxylation of phenylalanine to tyrosine has been effected by atmospheric oxygen in aqueous solution in the presence of 5,6,7,8‐tetrahydropterines, Fe II or Fe III , and EDTA, in a phosphate buffer at pH 6,9. A possible reaction mechanism is discussed.