Premium
De la chimie des ptérines. 15 e communication. Hydroxylation non‐enzymatique de la phénylalanine en tyrosine à l'aide de ptérines tétrahydrogénées
Author(s) -
Bobst A.,
Viscontini M.
Publication year - 1966
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19660490209
Subject(s) - chemistry , hydroxylation , aqueous solution , tyrosine , phenylalanine , enzyme , stereochemistry , medicinal chemistry , biochemistry , organic chemistry , amino acid
The non‐enzymatic hydroxylation of phenylalanine to tyrosine has been effected by atmospheric oxygen in aqueous solution in the presence of 5,6,7,8‐tetrahydropterines, Fe II or Fe III , and EDTA, in a phosphate buffer at pH 6,9. A possible reaction mechanism is discussed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom