Premium
Über Pterinchemie. 14. Mitteilung. Neues Verfahren zur Darstellung und Stabilisierung von Tetrahydrofolsäure und Tetrahydropterinen
Author(s) -
Bobst A.,
Viscontini M.
Publication year - 1966
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19660490208
Subject(s) - chemistry , catalytic hydrogenation , pyrazine , catalysis , medicinal chemistry , rhodium , organic chemistry
A new method for preparing hydrogenated pterines by catalytic hydrogenation in halogenated acids is described. The best results are obtained with platinum or rhodium in trifluoracetic acid. By this procedure the complete and selective hydrogenation of the pyrazine nucleus of pterine, its N‐methylated derivatives and of folic acid is effected in short time. For the first time the oxygen sensitive hydrogenation products have been isolated as hydrochlorides or sulphates. Some UV., NMR. and p K a data of 5,6, 7,8‐tetrahydrogenated pterines are given.