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Synthesen in der Isochinolinreihe Zur partiellen Ätherspaltung 6,7‐dimethoxy‐substituierter 3,4‐Dihydro‐isochinoline und Isochinoline
Author(s) -
Bruderer H.,
Brossi A.
Publication year - 1965
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19650480814
Subject(s) - chemistry , isoquinoline , hydrobromic acid , ether cleavage , hydrochloric acid , ether , medicinal chemistry , organic chemistry , stereochemistry
The selective ether cleavage observed with 6,7,8‐trimethoxy‐substituted 3,+‐dihydroisoquinolines and isoquinolines under the influence of 20% hydrochloric acid takes place in the analogous 6,7‐dimethoxy series with concentrated hydrobromic acid at 100°. This constitutes an easy route to 6‐methoxy‐7‐hydroxy‐isoquinoline derivatives.