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Recherches sur la formation et la transformation des esters LX. Sur la réaction des isothiocyanates avec des amino‐alcools soit libres soit estérifiés avec des acides du phosphore
Author(s) -
Cherbuliez Emile,
Baehler Br.,
Jindra H.,
Weber G.,
Wyss G.,
Rabinowitz J.
Publication year - 1965
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19650480513
Subject(s) - chemistry , medicinal chemistry
Aminoalkyl phosphoric monoesters with a primary or secondary amino group react with isothiocyanates in the presence of an alkali (2 moles of NaOH for 1 mole of the monoester and 1 mole of the isothiocyanate) to yield almost quantitatively the corresponding sodium N‐(aryl(aralkyl)‐thiocarbamyl)‐aminoalkyl phosphates; these thioureas are relatively soluble in water and generally also in methanol or ethanol.