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Synthetische Analoge des Hypertensins. VI. α‐ L ‐Asp(NH 2 ) 1 ‐aza‐α′‐homo‐Tyr 4 ‐Val 5 ‐Hypertensin II und β‐ L ‐Asp 1 ‐aza‐α′‐homo‐Tyr 4 ‐Val 5 ‐Hypertensin II
Author(s) -
Riniker B.,
Schwyzer R.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470826
Subject(s) - chemistry , azide , urea , isocyanate , stereochemistry , medicinal chemistry , organic chemistry , polyurethane
The use of the C URTIUS azide method for the synthesis of peptides is known to produce urea derivatives as side‐products due to partial rearrangement of the azide to an isocyanate. As model compounds for this type of reaction the two urea analogues of Val 5 ‐hypertensin II mentioned in the title have been synthesised.