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Adenosin‐5′‐monophosphat‐N(1)‐oxid Ein «ambivalentes» Ligandsystem
Author(s) -
Sigel H.,
Brintzinger H.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470706
Subject(s) - chemistry , deprotonation , adenosine monophosphate , adenosine , metal , oxide , chelation , metal ions in aqueous solution , ligand (biochemistry) , inorganic chemistry , ion , phosphate , molecule , stereochemistry , medicinal chemistry , receptor , organic chemistry , biochemistry
Structures of metal ion complexes of adenosine‐5′‐monophosphate‐N(1)‐oxide have been investigated by comparison of stability constants with those of adenosine‐5′‐monophosphate and by spectral measurements. In Cu 2+ ‐complexes of adenosine‐5′‐monophosphate‐N(1)‐oxide Cu 2+ is found to be bonded to the o ‐amino‐N‐oxide ligand group within the whole pH range investigated. On the other hand, in complexes of other bivalent 3 d ‐metal ions, the binding of the metal ion involves only the phosphate group at neutral or weakly acid pH, whereas at higher pH these complexes are deprotonated with simultaneous formation of a chelate at the o ‐amino‐N(1)‐oxide group. This behaviour can be explained in terms of the coordination tendency of the two coordination sites in the adenosine‐5′‐monophosphate‐N(1)‐oxide molecule towards the respective metal ions, if proper account is taken of the concurrent coordination of protons.