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In den Catecholamin‐Metabolismus eingreifende Substanzen. 3. 2,3‐Dihydroxyphenylacetamide und verwandte Verbindungen
Author(s) -
Carlsson A.,
Corrodi H.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470529
Subject(s) - chemistry , hydroxylation , tyrosine , stereochemistry , isopropyl , enzyme , phenylalanine , catechol , biochemistry , medicinal chemistry , amino acid
A series of new derivatives of 2,3‐dihydroxyphenylacetamide and congeners is described. Results are reported which support the view that these compounds inhibit in mammals the enzymatic hydroxylation of phenylalanine to tyrosine, of tryptophan to 5‐hydroxytryptophan, and of tyrosine to dopa, without inhibiting catechol‐O‐methyl‐transferase (COMT). In this regard they differ from the earlier published 3,4‐dihydroxyphenylacetamides (dopacetamides) Most potent are α‐ethoxy‐2,3‐dihydroxyphenylacetamide and α‐isopropyl‐2,3‐dihydroxyphenylacetamide.