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Synthèse d'analogues structuraux de l'élédoïsine (3ème partie)
Author(s) -
Sandrin Ed.,
Boissonnas R. A.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470526
Subject(s) - chemistry , moiety , stereochemistry , eledoisin , biological activity , peptide , biochemistry , receptor , substance p , neuropeptide , in vitro
The syntheses of a large number of Eledoisin analogues, some of which possess a more potent depressor effect than the original peptide, are described. Whereas the C‐terminal moiety of the Eledoisin molecule seems to be responsible for its biological action, its N‐terminal moiety can be deeply modified or even left out without considerable decrease of activity. There is apparently no relation between the isoelectric points of these analogous peptides and their biological properties.