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Syntheseversuche in der Emetinreihe 10. Mitteilung [1] Zur Oxydation von 2‐Dehydro‐emetin‐Verbindungen mit Quecksilber(II)‐acetat
Author(s) -
Gerecke M.,
Brossi A.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470502
Subject(s) - chemistry , medicinal chemistry , sodium borohydride , mercury (programming language) , nuclear chemistry , organic chemistry , catalysis , computer science , programming language
Trisdehydro‐emetinium salts of type IVa were prepared from rac. 2‐Dehydroisoemetine (IIa) by oxidation with mercury(II)‐acetate. IVa was reduced with sodium borohydride to a mixture of rac. 2‐dehydro‐emetine (IIIa) and IIa. The same sequence of reactions was carried out with the N‐acetyl derivatives IIc, IVc and IIIc. Under basic conditions or on heating, IVa breaks down to V and VI.