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Flavosemichinon‐Metallchelate: Modelle zur Erklärung der «active site» in den mitochondrialen Flavoenzymen. Zum Verhalten des Riboflavins gegen Metallionen III
Author(s) -
Hemmerich P.
Publication year - 1964
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19640470214
Subject(s) - chemistry , semiquinone , metal ions in aqueous solution , reactivity (psychology) , flavin group , chelation , metal , aqueous solution , riboflavin , ligand (biochemistry) , redox , inorganic chemistry , organic chemistry , enzyme , biochemistry , receptor , medicine , alternative medicine , pathology
The behaviour of half reduced isoalloxazine (flavocoenzyme) systems, riboflavin and analogues, has been studied acidimetrically and spectrophotometrically in aqueous solution, in the presence or absence of non‐redox d ‐metal ions. The metal has been found to combine selectively with the flavin semiquinone anion, forming deep red radical chelates with cornproportionation of the ligand system. Colour and reactivity of native metal‐containing flavoenzymes might be explained satisfactorily by this. Reference has been made to biological conclusions advanced elsewhere.