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L'inhibition de la décarboxylase de l'acide glutamique par le complexe cuivrique de l'isoniazide
Author(s) -
Mauron J.,
Bujar E.
Publication year - 1963
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19630460607
Subject(s) - chemistry , glutamate decarboxylase , kinetics , stereochemistry , enzyme , biochemistry , quantum mechanics , physics
The kinetics of the inhibition of the glutamic acid decarboxylase of Cl. Welchii S.R. 12 by the copper complex of isonicotinylhydrazide (INH) has been studied. While the decarboxylase is extremely resistant to INH, it is readily inhibited by the copper complex of INH. The rate of inhibition follows the characteristics of a bimolecular reaction.