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Recherches sur la formation et la transformation des esters XLV. Sur la phosphonylation des hydroxyacides, des hydroxynitriles et des hydroxyesters
Author(s) -
Cherbuliez Emile,
ČolakAntić Sl.,
Hunkeler F.,
Rabinowitz J.
Publication year - 1963
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19630460548
Subject(s) - chemistry , alkyl , medicinal chemistry , stereochemistry , hydrolysis , organic chemistry
Carboxy‐alkyl phenylphosphonic monoesters are obtained very easily by selective hydrolysis (in alcaline medium) of the corresponding carbamido‐ or cyano‐alkyl phenylphosphonic monoesters and sometimes of the corresponding carbethoxy‐alkyl phenylphosphonic monoesters and sometimes of the corresponding carbethoxy‐alkyl phenylphosphonic monoesters and sometimes of the corresponding carbethoxy‐alkyl phenylphosphonic monoesters. This general procedure cannot be carried out when the −CONH 2 , −CN or −COOR groups are fixed on the C next to the one bearing the phenylphosphonic monoester group; in this case, the monoester group is also very quickly clived in alcaline medium.