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Odeur et constitution XXI. Synthèses d'aldéhydes β‐éthyléniques cis . II
Author(s) -
Winter M.
Publication year - 1963
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19630460541
Subject(s) - chemistry , alkylation , methanol , ethylene , medicinal chemistry , hydrolysis , organic chemistry , catalysis
The authors describe a new general synthesis of cis ‐β‐ethylene aldehydes: the alkylation of 1‐methoxy‐1‐buten‐3‐yne to 1‐methoxy‐1‐alken‐3‐ynes followed by addition of methanol produces 1,1‐dimethoxy‐3‐alkynes. The catalytical reduction of these compounds to 1,1‐dimethoxy‐3‐alkenes followed by mild acidic hydrolysis yields cis ‐β‐ethylene aldehydes.