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Die Synthese optisch aktiver N‐Monomethyl‐Aminosäuren
Author(s) -
Quitt P.,
Hellerbach J.,
Vogler K.
Publication year - 1963
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19630460133
Subject(s) - chemistry , racemization , optically active , stereochemistry , amino acid , sequence (biology) , enantioselective synthesis , organic chemistry , catalysis , biochemistry
A synthesis of optically active N‐monomethylated amino acids (V) is described. It involves a three‐step process, starting from optically active amino acids (I) which are converted into their benzyl derivatives (III), subsequently methylated (IV) and finally hydrogenolyzed. The reaction sequence proceeds without racemization.