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Der Abbau von Desoxyribonucleinsäure durch Ascorbinsäure: Die intermediäre Bildung von OH‐Radikalen
Author(s) -
Berneis K.
Publication year - 1963
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19630460108
Subject(s) - chemistry , ascorbic acid , autoxidation , hydrogen peroxide , peroxidase , radical , catalase , dna , aqueous solution , antioxidant , biochemistry , organic chemistry , enzyme , food science
Ascorbic acid in aqueous solution in the presence of molecular oxygen causes a degradation of deoxyribonucleic acid (DNA). This degradation can be completely suppressed by the addition of catalase or of peroxidase. It is concluded that the degradation of the DNA is due to the formation of hydrogen peroxide during the autoxidation of the ascorbic acid. Hydrogen peroxide itself is not very efficient in degrading DNA, but it is reduced by ascorbic acid to OH radicals which degrade the DNA.