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Syntheseversuche in der Emetinreihe 8. Mitteilung Rac. Emetin‐Isomere der 2,3‐ cis ‐Reihe
Author(s) -
Brossi A.,
Schnider O.
Publication year - 1962
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19620450622
Subject(s) - emetine , chemistry , stereochemistry , acetic acid , organic chemistry , medicine , pharmacology
Abstract Final proof for the 2,3‐ cis configuration of the two benzo[a]quinolizine‐2‐acetic acid homoveratrylamides III and IV previously reported is presented. Starting from IV, the two new racemic emetine isomers XIV and XV have been synthesized. None of the four racemic emetine isomers XI, XII, XIV and XV shows an in vitro amoebicidal effect comparable with that of natural (−)‐emetine or racemic 2‐dehydroemetine.