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Synthèse de l'Asp(NH 2 ) 4 ‐oxytocine, de la Glu(NH 2 ) 5 ‐oxytocine et de l'Asp(NH 2 ) 4 ‐Glu(NH 2 ) 5 ‐oxytocine
Author(s) -
Jaquenoud PA.,
Boissonnas R. A.
Publication year - 1962
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19620450527
Subject(s) - chemistry , oxytocin , stereochemistry , medicinal chemistry , medicine
Three analogues of oxytocin in which the side chains of the amino acids in position 4 and 5 have been shortened or lengthened, i.e. Asp(NH 2 ) 4 ‐Oxytocin, Glu(NH 2 ) 5 ‐Oxytocin and Asp(NH 2 ) 4 ‐Glu(NH 2 ) 8 ‐Oxytocin, have been synthesized according to the scheme (3 + 6). Only the first of these analogues, which contains one CH 2 ‐group less than oxytocin, still exhibits important oxytocic activities.