Die Konstitution der isomeren Acetyldigitoxine. 48. Mitteilung über Herzglykoside

The reaction with phenylisocyanate transformed both acetyldigitoxin‐α and acetyldigitoxin‐β into their tris‐phenylurethanes (I and IX, respectively). By degradation of these derivatives, the constitutions of the degluco‐lanatosides could be elucidated. In acetyldigitoxin‐α, the characteristic acetyl group is attached to C‐3 of the terminal digitoxose unit, while the acetyl group of acetyldigitoxin‐β is located at C‐4 of the terminal sugar. The reversible rearrangement of the isomeric acetyl‐digitoxins represents an acyl migration.