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Über die Verrucarine und Roridine, eine Gruppe von cytostatisch hochwirksamen Antibiotica aus Myrothecium ‐Arten
Author(s) -
Härri E.,
Loeffler W.,
Sigg H. P.,
Stähelin H.,
Tamm Ch. Stoll Ch.,
Wiesinger D.
Publication year - 1962
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19620450314
Subject(s) - chemistry , stereochemistry , antifungal , microbiology and biotechnology , biology
From cultures of Myrothecium verrucaria (Albertini et Schweinitz) Ditmar ex Fries and Myrothecium roridum Tode ex Fries ( Fungi imperfecti ) a group of 10 new metabolites has been isolated in pure crystalline form and characterized by analytical and spectroscopic data: Verrucarin A (C 27 H 34 O 9 ), B (C 27 H 32 O 9 ), C, D, E, F, G, and Roridin A (C 29 H 40–42 O 9 ), B (C 28 H 46 O?) and Roridin C. They are neutral lipophilic compounds. The main constituents, Verrucarin A and B and Roridin A, show in vitro antifungal and high cytostatic activity.