Über die Verrucarine und Roridine, eine Gruppe von cytostatisch hochwirksamen Antibiotica aus  Myrothecium ‐Arten | Zendy

Härri E. | Zendy; Loeffler W. | Zendy; Sigg H. P. | Zendy; Stähelin H. | Zendy; Tamm Ch. Stoll Ch. | Zendy; Wiesinger D. | Zendy

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Über die Verrucarine und Roridine, eine Gruppe von cytostatisch hochwirksamen Antibiotica aus Myrothecium ‐Arten

Author(s) -

Härri E.,

Loeffler W.,

Sigg H. P.,

Stähelin H.,

Tamm Ch. Stoll Ch.,

Wiesinger D.

Publication year - 1962

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19620450314

Subject(s) - chemistry , stereochemistry , antifungal , microbiology and biotechnology , biology

From cultures of Myrothecium verrucaria (Albertini et Schweinitz) Ditmar ex Fries and Myrothecium roridum Tode ex Fries ( Fungi imperfecti ) a group of 10 new metabolites has been isolated in pure crystalline form and characterized by analytical and spectroscopic data: Verrucarin A (C 27 H 34 O 9 ), B (C 27 H 32 O 9 ), C, D, E, F, G, and Roridin A (C 29 H 40–42 O 9 ), B (C 28 H 46 O?) and Roridin C. They are neutral lipophilic compounds. The main constituents, Verrucarin A and B and Roridin A, show in vitro antifungal and high cytostatic activity.

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