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Nouvelle synthèse de la Bradykinine
Author(s) -
Guttmann St.,
Pless J.,
Boissonnas R. A.
Publication year - 1962
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19620450120
Subject(s) - chemistry , tosyl , glycine , arginine , bradykinin , stereochemistry , liquid ammonia , ammonia , amino acid , biochemistry , receptor
An improved synthesis of Bradykinin is described. N‐CBO‐G‐tosyl‐ L ‐arginyl‐ L ‐prolyl‐ L ‐prolyl‐glycine p ‐nitrophenyl ester and L ‐phenylalanyl‐ L ‐seryl‐ L ‐prolyl‐ L ‐phenylalanyl‐G‐tosyl‐ L ‐arginine are prepared and condensed together to N‐CBO‐G‐tosyl‐ L ‐arginyl‐ L ‐prolyl‐ L ‐prolyl‐glycyl‐ L ‐phenylalanyl‐ L ‐seryl‐ L ‐prolyl‐ L ‐phenylalanyl‐G‐tosyl‐ L ‐arginine. Removal of the protective groups by sodium in liquid ammonia affords directly pure Bradykinin in high yield.