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Über Steroide und Sexualhormone. 222. Mitteilung. 11,20‐Dihydroxy‐18,20‐cyclo‐pregnan‐Verbindungen
Author(s) -
Wehrli H.,
Cereghetti M.,
Schaffner K.,
Urech J.,
Vischer E.
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440714
Subject(s) - chemistry , pregnane , aspergillus ochraceus , stereochemistry , derivative (finance) , medicinal chemistry , mycotoxin , food science , ochratoxin a , financial economics , economics
11‐Oxygenated 18,20‐cyclo‐steroids have been prepared by two methods : 1. Irradiation of 3β, 11β‐diacetoxy‐20‐oxo‐5α‐pregnane and of 3‐ethylenedioxy‐11 α‐acetoxy‐20‐oxo‐Δ 5 ‐pregnene with ultraviolet light gave the corresponding (20S)‐20‐hydroxy‐18,20‐cyclo‐pregnane derivatives as major products. 2. Incubation of (20 S)‐3‐oxo‐20‐hydroxy‐Δ 4 ‐18, 20‐cyclo‐pregnene with an Aspergillus ochraceus W ILHELM culture furnished the corresponding 11 α‐hydroxy derivative.