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Synthèse d'analogues structuraux de la bradykinine
Author(s) -
Guttmann St.,
Boissonnas R. A.
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440627
Subject(s) - chemistry , stereochemistry , bradykinin , biochemistry , receptor
The synthesis of the four following analogues of Bradykinine is described in detail:H‐Arg‐Pro‐Gly‐Phe‐Ser‐Pro‐Phe‐Arg‐OH, H‐Arg‐Pro‐Pro‐Phe‐Gly ‐Ser ‐Phe‐Arg‐OH, H‐Arg‐Pro‐Gly‐Pro‐Phe‐Ser‐Phe‐Arg‐OH and H‐Arg‐Pro‐Gly‐Phe‐Ser‐Phe‐Arg‐OH. The first of these peptides exhibited a small bradykinin‐like activity. The three others were inactive.