Premium
Zur Verteilung von tritiertem Pentobarbital im Zentralnervensystem der Ratte
Author(s) -
Bernhard Karl,
Goetschel JeanDaniel,
Wagner Heribert
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440614
Subject(s) - chemistry , pentobarbital , pharmacology , medicine
We prepared a tritium labelled 5‐ethyl‐5‐(l‐methylbutyl)‐barbituric acid which was given to rats. After 60 minutes the specific activities of the telencephalon were equal to those of the blood. After three hours activities could be detected which remained nearly the same during the period of 24 hours for most parts of the nervous system. After 24 hours the total brain contained half as much pentobarbital as was found after one hour. The myelencephalon above all showed considerable quantities after doses of 25 mg had been given.