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Sekundäre Wasserstoff‐Isotopeneffekte bei der Nitrierung von Toluol
Author(s) -
Suhr H.,
Zollinger Hch.
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440418
Subject(s) - chemistry , nitration , toluene , medicinal chemistry , organic chemistry
The isomer ratio in the mono‐nitration of toluene and α‐d 3 ‐toluene has been measured by gas chromatographic separation. The percentage of o‐ and p ‐nitrotoluene is not influenced significantly by the isotopic substitution in the methyl group; there is, however, a difference in the formation of the m ‐isomer, demonstrating an inverse secondary isotope effect ( k H / k D = 0.94) for the substitution in m ‐position.