Synthèse de la Val 5 ‐ D ‐Phe 8 ‐angiotensine‐I et nouvelle synthèse de la Val 5 ‐angiotensine‐I

Val 5 ‐angiotensin‐I and one of its optical isomers, Val 5 ‐ D ‐Phe 8 ‐angiotensin‐I, were synthesized by a new way excluding any possibility of racemisation. The optical purity of the intermediary and final peptides was furthermore ascertained by enzymatic degradation. Val 5 ‐angiotensin‐I exhibited the full biological activity expected. Val 5 ‐ D ‐Phe 8 ‐angiotensin‐I was found to be practically inactive. It failed also to antagonize Val 5 ‐ or Ileu 5 ‐angiotensin‐I or to inhibit «converting enzyme».