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Synthese von L ‐Glutaminyl‐ L ‐histidyl‐ L ‐phenylalanyl‐ L ‐arginyl‐ L ‐tryptophyl‐glycin
Author(s) -
Kappeler H.
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440219
Subject(s) - chemistry , pentapeptide repeat , stereochemistry , derivative (finance) , peptide , biochemistry , financial economics , economics
The synthesis of the pentapeptide derivative Na α ‐Cbo‐N(Im)‐Bzl‐His‐Phe‐Arg‐Try‐Gly‐ONB and the synthesis of the hexapeptide H · Glu(NH 2 )‐His‐Phe‐Arg‐Try‐Gly · OH (acetate) comprising the sequence of six amino acid residues common to ACTH and α‐ and β‐MSH along various pathways is described in detail. This compound shows a very weak MSH‐activity (2 × 10 5 U/g).
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