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Synthesen in der Polymyxin‐Reihe. 5. Mitteilung. Synthese des cyclischen Decapeptids 8α
Author(s) -
Studer R. O.,
Vogler K.,
Lergier W.
Publication year - 1961
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19610440118
Subject(s) - chemistry , polymyxin , polymyxin b , stereochemistry , antibacterial activity , bacteria , antibiotics , biochemistry , biology , genetics
The cyclic decapeptide 8α, another of the four possible structures deduced for the natural polymyxin B 1 by the usual degradation methods, has been synthesized. It appears not to be identical with polymyxin B 1 in view of its reduced antibacterial activity in vitro .
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