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Die Beteiligung der Mevalonsäure an der Biosynthese der Ubichinone in der Ratte
Author(s) -
Gloor U.,
Schindler O.,
Wiss O.
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430727
Subject(s) - chemistry , mevalonic acid , quinone , side chain , stereochemistry , biosynthesis , terpenoid , biochemistry , enzyme , organic chemistry , polymer
By means of 2‐ 14 C‐ and 4‐ 14 C‐labelled mevalonic acid, it has been shown that in the rat the isoprenoid side‐chains of ubiquinone (45) and ubiquinone (50) are built up starting from this precursor. By chemical degradation, isolation of the fragments and determination of their radioactivity, it is concluded that mevalonic acid is used for the biosynthesis of the whole side‐chain. No radioactivity has been detected in the quinone ring.