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Influence des substituants sur la vitesse de racémisation des cétones à carbone dissymétrique en alpha
Author(s) -
Mills A. K.,
Smith A. E. Wilder
Publication year - 1960
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19600430705
Subject(s) - chemistry , substituent , ketone , reaction rate constant , carbon atom , stereochemistry , medicinal chemistry , organic chemistry , kinetics , ring (chemistry) , physics , quantum mechanics
The rates of racemisation, under constant conditions of pH and temperature, of two series of ketones with an asymmetric C‐atom in α have been determined. As would be expected, substituents in the α position to the keto group influence the rate of racemisation, and it has been found possible to assess the relative electron donating or electron attracting effect of aliphatic, aliphatic‐aromatic or aromatic substituents by measuring their influence on the rate of racemisation of a ketone containing the substituent considered.